Gene: DNASE1L3

Alternate names for this Gene: DHP2|DNAS1L3|LSD|SLEB16

Gene Summary: This gene encodes a member of the deoxyribonuclease I family. The encoded protein hydrolyzes DNA, is not inhibited by actin, and mediates the breakdown of DNA during apoptosis. Mutations in this gene are a cause of systemic lupus erythematosus-16. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene is located in Chromosome: 3

Location in Chromosome : 3p14.3

Description of this Gene: deoxyribonuclease 1 like 3

Type of Gene: protein-coding

rs35677470 in DNASE1L3 gene and Lupus Erythematosus, Systemic PMID 30573655 2019 Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases.

rs35677470 in DNASE1L3 gene and Myositis PMID 30573655 2019 Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases.

rs35677470 in DNASE1L3 gene and Rheumatoid Arthritis PMID 30573655 2019 Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases.

PMID 23143596 2012 High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.

rs35677470 in DNASE1L3 gene and Scleroderma, Limited PMID 24387989 2014 Immunochip analysis identifies multiple susceptibility loci for systemic sclerosis.

rs35677470 in DNASE1L3 gene and Systemic Scleroderma PMID 28314753 2017 Transethnic meta-analysis identifies GSDMA and PRDM1 as susceptibility genes to systemic sclerosis.

PMID 30573655 2019 Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases.

PMID 24387989 2014 Immunochip analysis identifies multiple susceptibility loci for systemic sclerosis.

rs6807301 in DNASE1L3 gene and Waist-Hip Ratio PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.