Gene: DOCK6

Alternate names for this Gene: AOS2|ZIR1

Gene Summary: This gene encodes a member of the dedicator of cytokinesis (DOCK) family of atypical guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with small GTPases and are components of intracellular signaling networks. The encoded protein is a group C DOCK protein and plays a role in actin cytoskeletal reorganization by activating the Rho GTPases Cdc42 and Rac1. Mutations in this gene are associated with Adams-Oliver syndrome 2.

Gene is located in Chromosome: 19

Location in Chromosome : 19p13.2

Description of this Gene: dedicator of cytokinesis 6

Type of Gene: protein-coding

Gene: ANGPTL8

Alternate names for this Gene: C19orf80|PRO1185|PVPA599|RIFL|TD26

Gene Summary:

Gene is located in Chromosome: 19

Location in Chromosome : 19p13.2

Description of this Gene: angiopoietin like 8

Type of Gene: protein-coding

rs145464906 in DOCK6;ANGPTL8 gene and High density lipoprotein measurement PMID 24507774 2014 Although we did not identify new genes associated with LDL-C, we did identify four low-frequency (frequencies between 0.1% and 2%) variants (ANGPTL8 rs145464906 [c.361C>T; p.Gln121*], PAFAH1B2 rs186808413 [c.482C>T; p.Ser161Leu], COL18A1 rs114139997 [c.331G>A; p.Gly111Arg], and PCSK7 rs142953140 [c.1511G>A; p.Arg504His]) with large effects on HDL-C and/or triglycerides.

rs59168178 in DOCK6;ANGPTL8 gene and Triglycerides measurement PMID 30275531 2018 Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.