Gene: DPEP2

Alternate names for this Gene: MBD2

Gene Summary: DPEP2 belongs to the membrane-bound dipeptidase (EC 3.4.13.19) family. These enzymes hydrolyze a variety of dipeptides, including leukotriene D4, the beta-lactam ring of some antibiotics, and cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation (Habib et al., 2003 [PubMed 12738806]).[supplied by OMIM, Mar 2008]. ##Evidence-Data-START## Transcript exon combination :: AK092884.1 [ECO:0000332] ##Evidence-Data-END##

Gene is located in Chromosome: 16

Location in Chromosome : 16q22.1

Description of this Gene: dipeptidase 2

Type of Gene: protein-coding

Gene: DUS2

Alternate names for this Gene: DUS2L|SMM1|URLC8

Gene Summary: This gene encodes a cytoplasmic protein that catalyzes the conversion of uridine residues to dihydrouridine in the D-loop of tRNA. The resulting modified bases confer enhanced regional flexibility to tRNA. The encoded protein may increase the rate of translation by inhibiting an interferon-induced protein kinase. This gene has been implicated in pulmonary carcinogenesis. Alternatively spliced transcript variants have been described for this gene.

Gene is located in Chromosome: 16

Location in Chromosome : 16q22.1

Description of this Gene: dihydrouridine synthase 2

Type of Gene: protein-coding