Gene: DPP6

Alternate names for this Gene: DPL1|DPPX|MRD33|VF2

Gene Summary: This gene encodes a single-pass type II membrane protein that is a member of the peptidase S9B family of serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Variations in this gene may be associated with susceptibility to amyotrophic lateral sclerosis and with idiopathic ventricular fibrillation. Alternative splicing results in multiple transcript variants.

Gene is located in Chromosome: 7

Location in Chromosome : 7q36.2

Description of this Gene: dipeptidyl peptidase like 6

Type of Gene: protein-coding

rs10260404 in DPP6 gene and Amyotrophic Lateral Sclerosis PMID 18084291 2008 Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis.

rs2110267 in DPP6 gene and Attention deficit hyperactivity disorder PMID 23527680 2013 Genome-wide association study of inattention and hyperactivity-impulsivity measured as quantitative traits.

rs118189482 in DPP6 gene and Chronic Obstructive Airway Disease PMID 26634245 2015 A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.

rs118189482 in DPP6 gene and Forced expiratory volume function PMID 26634245 2015 A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.

rs73169094 in DPP6 gene and Lean body mass PMID 28552196 2017 Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.

rs10251943 in DPP6 gene and Leukemia, Myelocytic, Acute PMID 27903959 2017 Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.

rs6464375 in DPP6 gene and Malignant neoplasm of pancreas PMID 20686608 2010 Genome-wide association study of pancreatic cancer in Japanese population.

rs6975879 in DPP6 gene and Narcolepsy PMID 19629137 2009 Genome-wide association database developed in the Japanese Integrated Database Project.

rs6464375 in DPP6 gene and Pancreatic carcinoma PMID 20686608 2010 Genome-wide association study of pancreatic cancer in Japanese population.

rs11243354 in DPP6 gene and Pelvic Organ Prolapse PMID 26545240 2015 Genetic Determinants of Pelvic Organ Prolapse among African American and Hispanic Women in the Women's Health Initiative.