Gene: EPHB1

Alternate names for this Gene: ELK|EPHT2|Hek6|NET

Gene Summary: Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.

Gene is located in Chromosome: 3

Location in Chromosome : 3q22.2

Description of this Gene: EPH receptor B1

Type of Gene: protein-coding

rs114807680 in EPHB1 gene and Adenocarcinoma of lung (disorder) PMID 29924316 2018 Genome-wide association study of familial lung cancer.

rs10935143 in EPHB1 gene and Body mass index PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs62270313 in EPHB1 gene and Epilepsy PMID 26220383 2015 GWAS identifies two susceptibility loci for lamotrigine-induced skin rash in patients with epilepsy.

rs183252871 in EPHB1 gene and Iron binding capacity total measurement PMID 28334935 2017 Genome-wide association study of iron traits and relation to diabetes in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL): potential genomic intersection of iron and glucose regulation?

rs62270313 in EPHB1 gene and Maculopapular Lesion PMID 26220383 2015 GWAS identifies two susceptibility loci for lamotrigine-induced skin rash in patients with epilepsy.

rs16842236 in EPHB1 gene and Narcolepsy PMID 19629137 2009 Genome-wide association database developed in the Japanese Integrated Database Project.

rs11918092 in EPHB1 gene and Secondary malignant neoplasm of colon and/or rectum PMID 30738427 2019 A genome-wide association study identifies single nucleotide polymorphisms associated with time-to-metastasis in colorectal cancer.

rs183252871 in EPHB1 gene and Total iron binding capacity function PMID 28334935 2017 Genome-wide association study of iron traits and relation to diabetes in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL): potential genomic intersection of iron and glucose regulation?