Gene: FAAH2

Alternate names for this Gene: AMDD

Gene Summary: This gene encodes a fatty acid amide hydrolase that shares a conserved protein motif with the amidase signature family of enzymes. The encoded enzyme is able to catalyze the hydrolysis of a broad range of bioactive lipids, including those from the three main classes of fatty acid amides; N-acylethanolamines, fatty acid primary amides and N-acyl amino acids. This enzyme has a preference for monounsaturated acyl chains as a substrate. Alternate splicing results in multiple transcript variants encoding distinct isoforms.

Gene is located in Chromosome: X

Location in Chromosome : Xp11.21

Description of this Gene: fatty acid amide hydrolase 2

Type of Gene: protein-coding

rs5914101 in FAAH2 gene and Age at menarche PMID 27182965 2016 Detection and interpretation of shared genetic influences on 42 human traits.

rs139470886 in FAAH2 gene and Alopecia PMID 28196072 2017 Genetic prediction of male pattern baldness.

rs7058676 in FAAH2 gene and Body Height PMID 31562340 2019 Characterizing rare and low-frequency height-associated variants in the Japanese population.

rs144226500 in FAAH2 gene and Diabetes Mellitus, Non-Insulin-Dependent PMID 30718926 2019 Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population.