Gene: FGF10

Alternate names for this Gene: -

Gene Summary: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing.

Gene is located in Chromosome: 5

Location in Chromosome : 5p12

Description of this Gene: fibroblast growth factor 10

Type of Gene: protein-coding

rs11742761 in FGF10 gene and Alzheimer's Disease PMID 26830138 2016 Family-based association analyses of imputed genotypes reveal genome-wide significant association of Alzheimer's disease with OSBPL6, PTPRG, and PDCL3.

rs13186320 in FGF10 gene and Breast Carcinoma PMID 29059683 2017 Association analysis identifies 65 new breast cancer risk loci.

rs6859730 in FGF10 gene and Forced expiratory volume function PMID 30804560 2019 New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

rs104893886 in FGF10 gene and Lacrimoauriculodentodigital syndrome PMID 16501574 2006 Mutations in different components of FGF signaling in LADD syndrome.

PMID 16630169 2006 LADD syndrome is caused by FGF10 mutations.

rs2121875 in FGF10 gene and Malignant neoplasm of prostate PMID 21743467 2011 Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study.

rs339502 in FGF10 gene and Narcolepsy PMID 19629137 2009 Genome-wide association database developed in the Japanese Integrated Database Project.

rs2121875 in FGF10 gene and Prostate carcinoma PMID 21743467 2011 Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study.

PMID 29892016 2018 Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.

rs1448039 in FGF10 gene and Vital capacity PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

PMID 30804560 2019 New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.