Gene: FGF5

Alternate names for this Gene: HBGF-5|Smag-82|TCMGLY

Gene Summary: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified as an oncogene, which confers transforming potential when transfected into mammalian cells. Targeted disruption of the homolog of this gene in mouse resulted in the phenotype of abnormally long hair, which suggested a function as an inhibitor of hair elongation. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene is located in Chromosome: 4

Location in Chromosome : 4q21.21

Description of this Gene: fibroblast growth factor 5

Type of Gene: protein-coding

rs4690116 in FGF5 gene and Alopecia PMID 28196072 2017 Genetic prediction of male pattern baldness.

rs4690116 in FGF5 gene and Alopecia, Androgenetic, 1 PMID 27182965 2016 Detection and interpretation of shared genetic influences on 42 human traits.

PMID 29146897 2017 GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk.

rs4690116 in FGF5 gene and Alopecia, Androgenetic, 2 PMID 27182965 2016 Detection and interpretation of shared genetic influences on 42 human traits.

PMID 29146897 2017 GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk.

rs4690116 in FGF5 gene and Alopecia, Androgenetic, 3 PMID 27182965 2016 Detection and interpretation of shared genetic influences on 42 human traits.

PMID 29146897 2017 GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk.

rs4690116 in FGF5 gene and Alopecia, Male Pattern PMID 27182965 2016 Detection and interpretation of shared genetic influences on 42 human traits.

PMID 29146897 2017 GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk.

rs4690116 in FGF5 gene and Androgenetic Alopecia PMID 27182965 2016 Detection and interpretation of shared genetic influences on 42 human traits.

PMID 29146897 2017 GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk.

rs17004869 in FGF5 gene and Diastolic blood pressure PMID 30487518 2018 Interethnic analyses of blood pressure loci in populations of East Asian and European descent.

rs1458046 in FGF5 gene and Hair Color PMID 30531825 2018 Genome-wide study of hair colour in UK Biobank explains most of the SNP heritability.

rs17004869 in FGF5 gene and Hypertensive disease PMID 30487518 2018 Interethnic analyses of blood pressure loci in populations of East Asian and European descent.

rs17004869 in FGF5 gene and Mean blood pressure PMID 30487518 2018 Interethnic analyses of blood pressure loci in populations of East Asian and European descent.

rs4690116 in FGF5 gene and Other alopecia PMID 27182965 2016 Detection and interpretation of shared genetic influences on 42 human traits.

PMID 29146897 2017 GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk.

rs17004869 in FGF5 gene and Systolic Pressure PMID 28135244 2017 Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.

PMID 30487518 2018 Interethnic analyses of blood pressure loci in populations of East Asian and European descent.

rs587777581 in FGF5 gene and Trichomegaly PMID 24989505 2014 FGF5 is a crucial regulator of hair length in humans.