Gene: FUT8

Alternate names for this Gene: CDGF|CDGF1

Gene Summary: This gene encodes an enzyme belonging to the family of fucosyltransferases. The product of this gene catalyzes the transfer of fucose from GDP-fucose to N-linked type complex glycopeptides. This enzyme is distinct from other fucosyltransferases which catalyze alpha1-2, alpha1-3, and alpha1-4 fucose addition. The expression of this gene may contribute to the malignancy of cancer cells and to their invasive and metastatic capabilities. Alternative splicing results in multiple transcript variants.

Gene is located in Chromosome: 14

Location in Chromosome : 14q23.3

Description of this Gene: fucosyltransferase 8

Type of Gene: protein-coding

rs1958560 in FUT8 gene and Age at menarche PMID 25231870 2014 Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.

rs2898818 in FUT8 gene and Body mass index PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs10483776 in FUT8 gene and High density lipoprotein measurement PMID 29083408 2017 Exome-wide association study of plasma lipids in >300,000 individuals.