Gene: GAB2

Alternate names for this Gene: -

Gene Summary: This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.

Gene is located in Chromosome: 11

Location in Chromosome : 11q14.1

Description of this Gene: GRB2 associated binding protein 2

Type of Gene: protein-coding

Gene: USP35

Alternate names for this Gene: -

Gene Summary: This gene encodes a member of the peptidase C19 family of ubiquitin-specific proteases. These deubiquitinating enzymes (DUBs) catalyze the removal of ubiquitin proteins from other proteins. The encoded protein associates with polarized mitochondria and has been shown to inhibit NF-kappa B activation and delay PARK2-mediated degradation of mitochondria. Expression of this gene is upregulated by the let-7a microRNA and reduced expression has been observed in human tumor tissues.

Gene is located in Chromosome: 11

Location in Chromosome : 11q14.1

Description of this Gene: ubiquitin specific peptidase 35

Type of Gene: protein-coding