Gene: GFRA2

Alternate names for this Gene: GDNFRB|NRTNR-ALPHA|NTNRA|RETL2|TRNR2

Gene Summary: Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene is located in Chromosome: 8

Location in Chromosome : 8p21.3

Description of this Gene: GDNF family receptor alpha 2

Type of Gene: protein-coding

rs7833426 in GFRA2 gene and Bipolar Disorder PMID 26806518 2016 Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study.

rs15881 in GFRA2 gene and Blood Protein Measurement PMID 29875488 2018 Genomic atlas of the human plasma proteome.

PMID 30072576 2018 Co-regulatory networks of human serum proteins link genetics to disease.

rs36196656 in GFRA2 gene and Frontotemporal dementia PMID 29724592 2018 Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study.