Gene: GGACT

Alternate names for this Gene: A2LD1

Gene Summary: The protein encoded by this gene aids in the proteolytic degradation of crosslinked fibrin by breaking down isodipeptide L-gamma-glutamyl-L-epsilon-lysine, a byproduct of fibrin degradation. The reaction catalyzed by the encoded gamma-glutamylaminecyclotransferase produces 5-oxo-L-proline and a free alkylamine. Two transcript variants encoding the same protein have been found for this gene.

Gene is located in Chromosome: 13

Location in Chromosome : 13q32.3

Description of this Gene: gamma-glutamylamine cyclotransferase

Type of Gene: protein-coding

rs117969561 in GGACT gene and Alzheimer's Disease PMID 26830138 2016 Family-based association analyses of imputed genotypes reveal genome-wide significant association of Alzheimer's disease with OSBPL6, PTPRG, and PDCL3.

rs9300607 in GGACT gene and Body Height PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.