Gene: GIPR

Alternate names for this Gene: PGQTL2

Gene Summary: This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes.

Gene is located in Chromosome: 19

Location in Chromosome : 19q13.32

Description of this Gene: gastric inhibitory polypeptide receptor

Type of Gene: protein-coding

rs10423928 in GIPR gene and Blood urea nitrogen measurement PMID 29403010 2018 Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.

rs10423928 in GIPR gene and Body mass index PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

PMID 22344219 2012 Meta-analysis identifies common variants associated with body mass index in east Asians.

PMID 28892062 2017 Genome-wide association study identifies 112 new loci for body mass index in the Japanese population.

PMID 24861553 2014 Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.

PMID 22344221 2012 Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations.

PMID 29273807 2018 Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.

PMID 28448500 2017 Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.

PMID 30239722 2019 Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.

rs11671664 in GIPR gene and Body mass index procedure PMID 22344219 2012 Meta-analysis identifies common variants associated with body mass index in east Asians.

PMID 24861553 2014 Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.

PMID 22344221 2012 Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations.

rs71338792 in GIPR gene and Breast Carcinoma PMID 29059683 2017 Association analysis identifies 65 new breast cancer risk loci.

rs11671664 in GIPR gene and Diabetes Mellitus, Non-Insulin-Dependent PMID 28869590 2017 Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.

PMID 29632382 2018 Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes.

rs11671664 in GIPR gene and Finding of body mass index PMID 24861553 2014 Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.

PMID 22344219 2012 Meta-analysis identifies common variants associated with body mass index in east Asians.

PMID 22344221 2012 Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations.

rs10423928 in GIPR gene and Glucose tolerance test PMID 20081857 2010 Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.

PMID 29093273 2017 Genetic determinants of circulating GIP and GLP-1 concentrations.

rs1800437 in GIPR gene and Insulin measurement PMID 29093273 2017 Genetic determinants of circulating GIP and GLP-1 concentrations.

rs138572433 in GIPR gene and Mean Corpuscular Volume (result) PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

rs10423928 in GIPR gene and Obesity PMID 23563607 2013 Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.

rs1800437 in GIPR gene and Physical Activity Measurement PMID 28448500 2017 Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.

rs34783010 in GIPR gene and Sodium measurement PMID 31409800 2019 GWAS for urinary sodium and potassium excretion highlights pathways shared with cardiovascular traits.

rs10423928 in GIPR gene and Systolic Pressure PMID 30578418 2019 Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.

rs1800437 in GIPR gene and Waist Circumference PMID 31453325 2019 Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank.

rs1800437 in GIPR gene and Waist-Hip Ratio PMID 30239722 2019 Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.

rs1800437 in GIPR gene and body fat percentage (physical finding) PMID 30593698 2019 Genomics of body fat percentage may contribute to sex bias in anorexia nervosa.