Gene: GNL3

Alternate names for this Gene: C77032|E2IG3|NNP47|NS

Gene Summary: The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene.

Gene is located in Chromosome: 3

Location in Chromosome : 3p21.1

Description of this Gene: G protein nucleolar 3

Type of Gene: protein-coding

Gene: GLT8D1

Alternate names for this Gene: AD-017|MSTP139

Gene Summary: This gene encodes a member of the glycosyltransferase family. The specific function of this protein has not been determined. Alternative splicing results in multiple transcript variants of this gene

Gene is located in Chromosome: 3

Location in Chromosome : 3p21.1

Description of this Gene: glycosyltransferase 8 domain containing 1

Type of Gene: protein-coding

rs6976 in GNL3;GLT8D1 gene and Degenerative polyarthritis PMID 22763110 2012 Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study.

rs6976 in GNL3;GLT8D1 gene and Major Depressive Disorder PMID 22472876 2013 A mega-analysis of genome-wide association studies for major depressive disorder.

rs6976 in GNL3;GLT8D1 gene and Osteoarthritis of hip PMID 30664745 2019 Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data.

PMID 30374069 2018 Meta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritis.

rs6976 in GNL3;GLT8D1 gene and Osteoarthritis, Knee PMID 30664745 2019 Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data.