Gene: GREB1

Alternate names for this Gene: -

Gene Summary: This gene is an estrogen-responsive gene that is an early response gene in the estrogen receptor-regulated pathway. It is thought to play an important role in hormone-responsive tissues and cancer. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Gene is located in Chromosome: 2

Location in Chromosome : 2p25.1

Description of this Gene: growth regulating estrogen receptor binding 1

Type of Gene: protein-coding

rs113467400 in GREB1 gene and Age at menarche PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs149940960 in GREB1 gene and Alanine aminotransferase measurement PMID 28090653 2017 Genome-Wide Study Links PNPLA3 Variant With Elevated Hepatic Transaminase After Acute Lymphoblastic Leukemia Therapy.

rs1435547 in GREB1 gene and Asthma PMID 25918132 2015 Genome-Wide Association Study Identifies Novel Loci Associated With Diisocyanate-Induced Occupational Asthma.

rs11674184 in GREB1 gene and Endometriosis PMID 28537267 2017 Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism.

PMID 23104006 2012 In addition, we establish an association of rs13394619 in GREB1 at 2p25.1 with endometriosis and identify a newly associated locus at 12q22 near VEZT (rs10859871).

rs16857586 in GREB1 gene and High density lipoprotein measurement PMID 30108155 2018 Genome-wide association study identifies novel recessive genetic variants for high TGs in an Arab population.

rs10929757 in GREB1 gene and Plexiform leiomyoma PMID 30194396 2018 Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits.

rs73175262 in GREB1 gene and Polysomnography PMID 23251661 2012 Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.

rs149940960 in GREB1 gene and Precursor Cell Lymphoblastic Leukemia Lymphoma PMID 28090653 2017 Genome-Wide Study Links PNPLA3 Variant With Elevated Hepatic Transaminase After Acute Lymphoblastic Leukemia Therapy.

rs149940960 in GREB1 gene and Serum Alanine Aminotransferase Measurement PMID 28090653 2017 Genome-Wide Study Links PNPLA3 Variant With Elevated Hepatic Transaminase After Acute Lymphoblastic Leukemia Therapy.

rs10929757 in GREB1 gene and Uterine Fibroids PMID 30194396 2018 Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits.