Gene: HCRT

Alternate names for this Gene: NRCLP1|OX|PPOX

Gene Summary: This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis.

Gene is located in Chromosome: 17

Location in Chromosome : 17q21.2

Description of this Gene: hypocretin neuropeptide precursor

Type of Gene: protein-coding

rs104894574 in HCRT gene and Narcolepsy 1 PMID 10973318 2000 A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains.