Gene: HIVEP2

Alternate names for this Gene: HIV-EP2|MBP-2|MIBP1|MRD43|SHN2|ZAS2|ZNF40B

Gene Summary: This gene encodes a member of a family of closely related, large, zinc finger-containing transcription factors. The encoded protein regulates transcription by binding to regulatory regions of various cellular and viral genes that maybe involved in growth, development and metastasis. The protein contains the ZAS domain comprised of two widely separated regions of zinc finger motifs, a stretch of highly acidic amino acids and a serine/threonine-rich sequence.

Gene is located in Chromosome: 6

Location in Chromosome : 6q24.2

Description of this Gene: HIVEP zinc finger 2

Type of Gene: protein-coding

rs12154082 in HIVEP2 gene and Body Height PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs765876 in HIVEP2 gene and Body Weight PMID 28552196 2017 Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.

rs198665 in HIVEP2 gene and Body mass index PMID 30239722 2019 Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.

PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs62430713 in HIVEP2 gene and Cardiovascular Diseases PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs4896604 in HIVEP2 gene and Coronary Artery Disease PMID 29212778 2018 Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease.

rs3383 in HIVEP2 gene and Diabetes Mellitus, Non-Insulin-Dependent PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs9390032 in HIVEP2 gene and Eosinophil count procedure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs1554274371 in HIVEP2 gene and Multiple congenital anomalies PMID 23020937 2012 Range of genetic mutations associated with severe non-syndromic sporadic intellectual disability: an exome sequencing study.

PMID 22294689 2012 Genome-wide repression of NF-κB target genes by transcription factor MIBP1 and its modulation by O-linked β-N-acetylglucosamine (O-GlcNAc) transferase.

PMID 26153216 2016 Loss-of-function variants in HIVEP2 are a cause of intellectual disability.

PMID 27003583 2016 Mutations in HIVEP2 are associated with developmental delay, intellectual disability, and dysmorphic features.

rs198663 in HIVEP2 gene and Systolic Pressure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.