Gene: HMGA2-AS1

Alternate names for this Gene: -

Gene Summary:

Gene is located in Chromosome: 12

Location in Chromosome : 12q14.3

Description of this Gene: HMGA2 antisense RNA 1

Type of Gene: ncRNA

Gene: HMGA2

Alternate names for this Gene: BABL|HMGI-C|HMGIC|LIPO|SRS5|STQTL9

Gene Summary: This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene is located in Chromosome: 12

Location in Chromosome : 12q14.3

Description of this Gene: high mobility group AT-hook 2

Type of Gene: protein-coding

rs9668162 in HMGA2-AS1;HMGA2 gene and Diabetes Mellitus, Non-Insulin-Dependent PMID 22325160 2012 Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci.

rs189339 in HMGA2-AS1;HMGA2 gene and Red Blood Cell Count measurement PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.