Gene: HYKK

Alternate names for this Gene: AGPHD1

Gene Summary:

Gene is located in Chromosome: 15

Location in Chromosome : 15q25.1

Description of this Gene: hydroxylysine kinase

Type of Gene: protein-coding

rs2036534 in HYKK gene and Adenocarcinoma of lung (disorder) PMID 19836008 2009 A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma.

rs8034191 in HYKK gene and Carcinoma of lung PMID 19654303 2009 A meta-analysis provided increased support that variation at 15q25.1 (rs8034191; P = 3.24 x 10(-26)), 5p15.33 (rs4975616; P = 2.99 x 10(-9)), and 6p21.33 (rs3117582; P = 4.46 x 10(-10)) influences lung cancer risk.

PMID 18385676 2008 Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1.

PMID 18385738 2008 A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25.

PMID 18780872 2008 The risk of lung cancer was more than fivefold higher among those subjects who had both a family history of lung cancer and two copies of high-risk alleles rs8034191 (odds ratio [OR] = 7.20, 95% confidence interval [CI] = 2.21 to 23.37) or rs1051730 (OR = 5.67, CI = 2.21 to 14.60, both of which were located in the 15q24-25.1 locus, than among control subjects.

rs10519203 in HYKK gene and Chronic Obstructive Airway Disease PMID 26634245 2015 A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.

PMID 21685187 2011 Genome-wide association study of smoking behaviours in patients with COPD.

PMID 19300482 2009 The C allele of the rs8034191 SNP was estimated to have a population attributable risk for COPD of 12.2%.

PMID 21921092 2011 Identification of FGF7 as a novel susceptibility locus for chronic obstructive pulmonary disease.

PMID 29631575 2018 The genetics of smoking in individuals with chronic obstructive pulmonary disease.

rs9788721 in HYKK gene and Cotinine measurement PMID 29631575 2018 The genetics of smoking in individuals with chronic obstructive pulmonary disease.

rs10519203 in HYKK gene and Fibrinogen assay PMID 25551457 2014 No evidence for genome-wide interactions on plasma fibrinogen by smoking, alcohol consumption and body mass index: results from meta-analyses of 80,607 subjects.

rs10519203 in HYKK gene and Forced expiratory volume function PMID 26634245 2015 A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.

rs2036534 in HYKK gene and Malignant neoplasm of lung PMID 19654303 2009 Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study.

PMID 22899653 2012 Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls.

PMID 18978787 2008 Common 5p15.33 and 6p21.33 variants influence lung cancer risk.

PMID 18385676 2008 Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1.

PMID 18385738 2008 A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25.

PMID 18780872 2008 The risk of lung cancer was more than fivefold higher among those subjects who had both a family history of lung cancer and two copies of high-risk alleles rs8034191 (odds ratio [OR] = 7.20, 95% confidence interval [CI] = 2.21 to 23.37) or rs1051730 (OR = 5.67, CI = 2.21 to 14.60, both of which were located in the 15q24-25.1 locus, than among control subjects.

PMID 19654303 2009 A meta-analysis provided increased support that variation at 15q25.1 (rs8034191; P = 3.24 x 10(-26)), 5p15.33 (rs4975616; P = 2.99 x 10(-9)), and 6p21.33 (rs3117582; P = 4.46 x 10(-10)) influences lung cancer risk.

PMID 18978790 2008 Lung cancer susceptibility locus at 5p15.33.

rs8034191 in HYKK gene and Nasopharyngeal carcinoma PMID 20512145 2010 A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci.

rs8031948 in HYKK gene and Respiratory Function Tests PMID 22837378 2012 Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.

rs28437878 in HYKK gene and Schizophrenia PMID 30285260 2019 Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect.

rs34684276 in HYKK gene and Smoking PMID 26440539 2015 Genome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependence.

PMID 27669027 2017 Genome-Wide Association Study of the Genetic Determinants of Emphysema Distribution.

rs10519203 in HYKK gene and Smoking Behaviors PMID 20418888 2010 Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior.

PMID 20418889 2010 Meta-analysis and imputation refines the association of 15q25 with smoking quantity.

PMID 20418890 2010 Genome-wide meta-analyses identify multiple loci associated with smoking behavior.

PMID 27669027 2017 Genome-Wide Association Study of the Genetic Determinants of Emphysema Distribution.

rs8042849 in HYKK gene and Vital capacity PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs10519203 in HYKK gene and response to bronchodilator PMID 26634245 2015 A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.