Gene: IKBKE

Alternate names for this Gene: IKK-E|IKK-i|IKKE|IKKI

Gene Summary: IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).[supplied by OMIM, Oct 2009].

Gene is located in Chromosome: 1

Location in Chromosome : 1q32.1

Description of this Gene: inhibitor of nuclear factor kappa B kinase subunit epsilon

Type of Gene: protein-coding

rs17022427 in IKBKE gene and Eosinophil count procedure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs2297550 in IKBKE gene and Lupus Erythematosus, Systemic PMID 27399966 2016 Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus.

rs41298997 in IKBKE gene and Psoriasis PMID 28537254 2017 Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants.