Gene: IL10RA

Alternate names for this Gene: CD210|CD210a|CDW210A|HIL-10R|IL-10R1|IL10R

Gene Summary: The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene.

Gene is located in Chromosome: 11

Location in Chromosome : 11q23.3

Description of this Gene: interleukin 10 receptor subunit alpha

Type of Gene: protein-coding

rs4252273 in IL10RA gene and High density lipoprotein measurement PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

rs137853579 in IL10RA gene and INFLAMMATORY BOWEL DISEASE 28, AUTOSOMAL RECESSIVE PMID 23839161 2013 Interleukin-10 receptor mutations in children with neonatal-onset Crohn's disease and intractable ulcerating enterocolitis.

PMID 24785691 2014 Very early-onset inflammatory bowel disease (IBD) in infancy is a different disease entity from adult-onset IBD; one form of interleukin-10 receptor mutations.

PMID 19890111 2009 Inflammatory bowel disease and mutations affecting the interleukin-10 receptor.

rs4252273 in IL10RA gene and Serum HDL cholesterol measurement PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.