Gene: IL12A-AS1
Alternate names for this Gene:
Gene Summary:
Gene is located in Chromosome:
Location in Chromosome :
Description of this Gene:
Type of Gene:
rs17810546 in
IL12A-AS1 gene and
Asthma
PMID 21150878 2011 Association between ORMDL3, IL1RL1 and a deletion on chromosome 17q21 with asthma risk in Australia.
rs17810546 in
IL12A-AS1 gene and
Autoimmune Diseases
PMID 21383967 2011 Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci.
rs17810546 in
IL12A-AS1 gene and
Behcet Syndrome
PMID 23291587 2013 Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1.
PMID 25799145 2015 Genome-wide association study in an admixed case series reveals IL12A as a new candidate in Behçet disease.
PMID 27548383 2016 Genetic Analysis with the Immunochip Platform in Behçet Disease. Identification of Residues Associated in the HLA Class I Region and New Susceptibility Loci.
rs6441286 in
IL12A-AS1 gene and
Biliary cirrhosis
PMID 19458352 2009 Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants.
PMID 20639880 2010 Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis.
rs1353248 in
IL12A-AS1 gene and
Celiac Disease
PMID 22057235 2011 Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease.
PMID 20190752 2010 Multiple common variants for celiac disease influencing immune gene expression.
PMID 18311140 2008 Newly identified genetic risk variants for celiac disease related to the immune response.
PMID 25920553 2016 Common polygenic variation in coeliac disease and confirmation of ZNF335 and NIFA as disease susceptibility loci.
rs76830965 in
IL12A-AS1 gene and
Eosinophil count procedure
PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
rs17810546 in
IL12A-AS1 gene and
Immune System Diseases
PMID 21383967 2011 Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci.
rs564799 in
IL12A-AS1 gene and
Lupus Erythematosus, Systemic
PMID 26502338 2015 Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus.
PMID 27399966 2016 Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus.
PMID 28714469 2017 Transancestral mapping and genetic load in systemic lupus erythematosus.
rs6799788 in
IL12A-AS1 gene and
Major Depressive Disorder
PMID 23377640 2013 Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
rs1014486 in
IL12A-AS1 gene and
Multiple Sclerosis
PMID 24076602 2013 Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.
PMID 22190364 2011 Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
rs11918142 in
IL12A-AS1 gene and
Non-obstructive azoospermia
PMID 22197933 2011 A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia.
rs1353248 in
IL12A-AS1 gene and
Oral Ulcer
PMID 30837455 2019 Genome wide analysis for mouth ulcers identifies associations at immune regulatory loci.
PMID 30837455 2019 This study finds 97 variants which alter the odds of developing non-specific mouth ulcers and replicate these in an independent cohort (n = 355,744) (lead variant after meta-analysis: rs76830965, near IL12A, OR 0.72 (95% CI: 0.71, 0.73); P = 4.4e-483).
rs1651081 in
IL12A-AS1 gene and
Primary biliary cirrhosis
PMID 22961000 2012 Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis.
PMID 22936693 2012 Immunochip analyses identify a novel risk locus for primary biliary cirrhosis at 13q14, multiple independent associations at four established risk loci and epistasis between 1p31 and 7q32 risk variants.
PMID 21399635 2011 Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.
PMID 19458352 2009 Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants.
PMID 20639880 2010 Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis.
PMID 28062665 2017 Genome-wide association studies identify PRKCB as a novel genetic susceptibility locus for primary biliary cholangitis in the Japanese population.
rs77583790 in
IL12A-AS1 gene and
Scleroderma, Limited
PMID 24387989 2014 Immunochip analysis identifies multiple susceptibility loci for systemic sclerosis.
rs485497 in
IL12A-AS1 gene and
Sjogren's Syndrome
PMID 24097067 2013 Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome.
rs589446 in
IL12A-AS1 gene and
Systemic Scleroderma
PMID 31672989 2019 GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways.
PMID 24387989 2014 Immunochip analysis identifies multiple susceptibility loci for systemic sclerosis.