Gene: INS-IGF2

Alternate names for this Gene: INSIGF

Gene Summary: This locus includes two alternatively spliced read-through transcript variants which align to the INS gene in the 5' region and to the IGF2 gene in the 3' region. One transcript is predicted to encode a protein which shares the N-terminus with the INS protein but has a distinct and longer C-terminus, whereas the other transcript is a candidate for nonsense-mediated decay (NMD). The transcripts are imprinted and are paternally expressed in the limb and eye.

Gene is located in Chromosome: 11

Location in Chromosome : 11p15.5

Description of this Gene: INS-IGF2 readthrough

Type of Gene: protein-coding

Gene: IGF2

Alternate names for this Gene: C11orf43|GRDF|IGF-II|PP9974|SRS3

Gene Summary: This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene is located in Chromosome: 11

Location in Chromosome : 11p15.5

Description of this Gene: insulin like growth factor 2

Type of Gene: protein-coding

Gene: IGF2-AS

Alternate names for this Gene: IGF2-AS1|IGF2AS|PEG8

Gene Summary: This gene is expressed in antisense to the insulin-like growth factor 2 (IGF2) gene and is imprinted and paternally expressed. It is thought to be non-coding because the putative protein is not conserved and translation is predicted to trigger nonsense mediated decay (NMD). Transcripts from this gene are produced in tumors and may function to suppress cell growth. Alternative splicing results in multiple transcript variants.

Gene is located in Chromosome: 11

Location in Chromosome : 11p15.5

Description of this Gene: IGF2 antisense RNA

Type of Gene: ncRNA

rs149483638 in INS-IGF2;IGF2;IGF2-AS gene and Diabetes Mellitus, Non-Insulin-Dependent PMID 28838971 2017 A Loss-of-Function Splice Acceptor Variant in IGF2 Is Protective for Type 2 Diabetes.

rs3741210 in INS-IGF2;IGF2;IGF2-AS gene and Systolic Pressure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs3741210 in INS-IGF2;IGF2;IGF2-AS gene and Uric acid measurement (procedure) PMID 31578528 2019 Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels.