Gene: INS-IGF2

Alternate names for this Gene: INSIGF

Gene Summary: This locus includes two alternatively spliced read-through transcript variants which align to the INS gene in the 5' region and to the IGF2 gene in the 3' region. One transcript is predicted to encode a protein which shares the N-terminus with the INS protein but has a distinct and longer C-terminus, whereas the other transcript is a candidate for nonsense-mediated decay (NMD). The transcripts are imprinted and are paternally expressed in the limb and eye.

Gene is located in Chromosome: 11

Location in Chromosome : 11p15.5

Description of this Gene: INS-IGF2 readthrough

Type of Gene: protein-coding

rs3842770 in INS-IGF2 gene and Diabetes Mellitus, Non-Insulin-Dependent PMID 25102180 2014 Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes.

rs11564722 in INS-IGF2 gene and Glomerular Filtration Rate PMID 31152163 2019 A catalog of genetic loci associated with kidney function from analyses of a million individuals.

rs11564722 in INS-IGF2 gene and Red Blood Cell Count measurement PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs3842763 in INS-IGF2 gene and Waist-Hip Ratio PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.