Gene: INTS8

Alternate names for this Gene: C8orf52|INT8|NEDCHS

Gene Summary: This gene encodes a subunit of the Integrator complex which is involved in the cleavage of small nuclear RNAs U1 and U2 within the nucleus. The encoded protein associates with RNA polymerase II and is recruited to the U1 and U2 small nuclear RNA genes. Alternative splicing results in multiple transcript variants.

Gene is located in Chromosome: 8

Location in Chromosome : 8q22.1

Description of this Gene: integrator complex subunit 8

Type of Gene: protein-coding

rs17359493 in INTS8 gene and Diabetes Mellitus, Non-Insulin-Dependent PMID 25102180 2014 Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes.

rs143773045 in INTS8 gene and Finding of Mean Corpuscular Hemoglobin PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.