Gene: KLF8

Alternate names for this Gene: BKLF3|ZNF741

Gene Summary: This gene encodes a protein which is a member of the Sp/KLF family of transcription factors. Members of this family contain a C-terminal DNA-binding domain with three Kruppel-like zinc fingers. The encoded protein is thought to play an important role in the regulation of epithelial to mesenchymal transition, a process which occurs normally during development but also during metastasis. A pseudogene has been identified on chromosome 16. Alternative splicing results in multiple transcript variants.

Gene is located in Chromosome: X

Location in Chromosome : Xp11.21

Description of this Gene: Kruppel like factor 8

Type of Gene: protein-coding

rs73206583 in KLF8 gene and Alopecia PMID 28196072 2017 Genetic prediction of male pattern baldness.

rs143149578 in KLF8 gene and Alopecia, Androgenetic, 1 PMID 27182965 2016 Detection and interpretation of shared genetic influences on 42 human traits.

rs143149578 in KLF8 gene and Alopecia, Androgenetic, 2 PMID 27182965 2016 Detection and interpretation of shared genetic influences on 42 human traits.

rs143149578 in KLF8 gene and Alopecia, Androgenetic, 3 PMID 27182965 2016 Detection and interpretation of shared genetic influences on 42 human traits.

rs143149578 in KLF8 gene and Alopecia, Male Pattern PMID 27182965 2016 Detection and interpretation of shared genetic influences on 42 human traits.

rs143149578 in KLF8 gene and Androgenetic Alopecia PMID 27182965 2016 Detection and interpretation of shared genetic influences on 42 human traits.

rs143149578 in KLF8 gene and Other alopecia PMID 27182965 2016 Detection and interpretation of shared genetic influences on 42 human traits.

rs10855058 in KLF8 gene and Prostate specific antigen measurement PMID 28139693 2017 Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer.

rs183056377 in KLF8 gene and Smoking PMID 26053186 2015 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer.

rs183056377 in KLF8 gene and Smoking Behaviors PMID 26053186 2015 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer.