Gene: LIN28B

Alternate names for this Gene: CSDD2

Gene Summary: The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation.

Gene is located in Chromosome: 6

Location in Chromosome : 6q16.3-q21

Description of this Gene: lin-28 homolog B

Type of Gene: protein-coding

rs11285463 in LIN28B gene and Age at menarche PMID 29773799 2018 Elucidating the genetic architecture of reproductive ageing in the Japanese population.

PMID 19448620 2009 Meta-analysis of genome-wide association data identifies two loci influencing age at menarche.

PMID 19448622 2009 Genome-wide association study identifies sequence variants on 6q21 associated with age at menarche.

PMID 19448623 2009 We carried out a genome-wide association study for age at menarche in 4,714 women and report an association in LIN28B on chromosome 6 (rs314276, minor allele frequency (MAF) = 0.33, P = 1.5 × 10(-8)).

PMID 21102462 2010 Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.

PMID 19448621 2009 Genome-wide association studies identify loci associated with age at menarche and age at natural menopause.

PMID 23667675 2013 Here, we identified an association between SNP (single nucleotide polymorphism) rs364663 at the LIN28B locus and AAM, with a P-value of 5.49×10(-7) and an effect size of 0.089 (year).

rs314277 in LIN28B gene and Age at menopause PMID 19448621 2009 Genome-wide association studies identify loci associated with age at menarche and age at natural menopause.

PMID 29773799 2018 Elucidating the genetic architecture of reproductive ageing in the Japanese population.

rs314263 in LIN28B gene and Body Fat Distribution PMID 30664634 2019 Genome-wide association study of body fat distribution identifies adiposity loci and sex-specific genetic effects.

rs314263 in LIN28B gene and Body Height PMID 31217584 2019 Genetic analyses of diverse populations improves discovery for complex traits.

PMID 25282103 2014 Defining the role of common variation in the genomic and biological architecture of adult human height.

PMID 18391951 2008 Many sequence variants affecting diversity of adult human height.

PMID 28552196 2017 Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.

PMID 18391950 2008 Identification of ten loci associated with height highlights new biological pathways in human growth.

PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs314268 in LIN28B gene and Height PMID 18391951 2008 Many sequence variants affecting diversity of adult human height.

PMID 18391950 2008 Identification of ten loci associated with height highlights new biological pathways in human growth.

rs17065417 in LIN28B gene and Neuroblastoma PMID 28545128 2017 Common variants upstream of MLF1 at 3q25 and within CPZ at 4p16 associated with neuroblastoma.

PMID 22941191 2012 Expression of LIN28B and let-7 miRNA correlated with rs17065417 genotype in neuroblastoma cell lines, and we observed significant growth inhibition upon depletion of LIN28B, specifically in neuroblastoma cells that were homozygous for the risk allele.

rs395962 in LIN28B gene and Physical Activity Measurement PMID 28448500 2017 Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.

rs160593 in LIN28B gene and Schizophrenia PMID 30285260 2019 Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect.

PMID 28991256 2017 Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia.

PMID 26198764 2015 Genome-wide association study of schizophrenia in Ashkenazi Jews.

rs395962 in LIN28B gene and Smoking PMID 28443625 2017 Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.

rs395962 in LIN28B gene and Smoking Behaviors PMID 28443625 2017 Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.

rs314263 in LIN28B gene and Tonometry PMID 29617998 2018 Genome-wide association analyses identify new loci influencing intraocular pressure.

rs370771 in LIN28B gene and Vital capacity PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.