Gene: LIPC-AS1

Alternate names for this Gene:

Gene Summary:

Gene is located in Chromosome:

Location in Chromosome :

Description of this Gene:

Type of Gene:

Gene: LIPC

Alternate names for this Gene: HDLCQ12|HL|HTGL|LIPH

Gene Summary: LIPC encodes hepatic triglyceride lipase, which is expressed in liver. LIPC has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake.

Gene is located in Chromosome: 15

Location in Chromosome : 15q21.3

Description of this Gene: lipase C, hepatic type

Type of Gene: protein-coding

Gene: ALDH1A2

Alternate names for this Gene: RALDH(II)|RALDH2|RALDH2-T

Gene Summary: This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a hormonal signaling molecule that functions in developing and adult tissues. The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels which facilitate posterior organ development and prevent spina bifida. Four transcript variants encoding distinct isoforms have been identified for this gene.

Gene is located in Chromosome: 15

Location in Chromosome : 15q21.3

Description of this Gene: aldehyde dehydrogenase 1 family member A2

Type of Gene: protein-coding

rs11858164 in LIPC-AS1;LIPC;ALDH1A2 gene and High density lipoprotein measurement PMID 18193046 2008 Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides.

PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

PMID 30926973 2019 Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.

PMID 29507422 2018 A large electronic-health-record-based genome-wide study of serum lipids.

rs11858164 in LIPC-AS1;LIPC;ALDH1A2 gene and Serum HDL cholesterol measurement PMID 18193046 2008 Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides.

PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

rs10152202 in LIPC-AS1;LIPC;ALDH1A2 gene and Serum albumin measurement PMID 22286219 2012 Genome-wide association study identifies multiple loci influencing human serum metabolite levels.

PMID 23281178 2013 A genome-wide assessment of variability in human serum metabolism.

rs261342 in LIPC-AS1;LIPC;ALDH1A2 gene and Serum total cholesterol measurement PMID 29507422 2018 A large electronic-health-record-based genome-wide study of serum lipids.

PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

rs261342 in LIPC-AS1;LIPC;ALDH1A2 gene and Triglycerides measurement PMID 29507422 2018 A large electronic-health-record-based genome-wide study of serum lipids.

PMID 30926973 2019 Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.

PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.