Gene: LOC105371843

Alternate names for this Gene:

Gene Summary:

Gene is located in Chromosome:

Location in Chromosome :

Description of this Gene:

Type of Gene:

Gene: RAD51C

Alternate names for this Gene: BROVCA3|FANCO|R51H3|RAD51L2

Gene Summary: This gene is a member of the RAD51 family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51 and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with other RAD51 paralogs and is reported to be important for Holliday junction resolution. Mutations in this gene are associated with Fanconi anemia-like syndrome. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing results in multiple transcript variants.

Gene is located in Chromosome: 17

Location in Chromosome : 17q22

Description of this Gene: RAD51 paralog C

Type of Gene: protein-coding

rs587781410 in LOC105371843;RAD51C gene and BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 3 PMID 22538716 2012 Germline RAD51C mutations confer susceptibility to ovarian cancer.

PMID 26681312 2016 Pathogenic and likely pathogenic variant prevalence among the first 10,000 patients referred for next-generation cancer panel testing.

PMID 24139550 2013 Germline mutation in the RAD51B gene confers predisposition to breast cancer.

PMID 12966089 2003 Identification of functional domains in the RAD51L2 (RAD51C) protein and its requirement for gene conversion.

PMID 26057125 2015 Mutation Analysis of the RAD51C and RAD51D Genes in High-Risk Ovarian Cancer Patients and Families from the Czech Republic.

PMID 26822949 2016 Hereditary truncating mutations of DNA repair and other genes in BRCA1/BRCA2/PALB2-negatively tested breast cancer patients.

PMID 26261251 2015 Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population.

rs1555603056 in LOC105371843;RAD51C gene and FANCONI ANEMIA, COMPLEMENTATION GROUP O PMID 12966089 2003 Identification of functional domains in the RAD51L2 (RAD51C) protein and its requirement for gene conversion.

PMID 27616075 2017 Gene panel sequencing in familial breast/ovarian cancer patients identifies multiple novel mutations also in genes others than BRCA1/2.

PMID 22538716 2012 Germline RAD51C mutations confer susceptibility to ovarian cancer.

PMID 26261251 2015 Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population.

PMID 25452441 2015 Inherited mutations in 17 breast cancer susceptibility genes among a large triple-negative breast cancer cohort unselected for family history of breast cancer.

PMID 26681312 2016 Pathogenic and likely pathogenic variant prevalence among the first 10,000 patients referred for next-generation cancer panel testing.

PMID 24139550 2013 Germline mutation in the RAD51B gene confers predisposition to breast cancer.

PMID 26057125 2015 Mutation Analysis of the RAD51C and RAD51D Genes in High-Risk Ovarian Cancer Patients and Families from the Czech Republic.

PMID 28905878 2017 Detecting splicing patterns in genes involved in hereditary breast and ovarian cancer.

PMID 26822949 2016 Hereditary truncating mutations of DNA repair and other genes in BRCA1/BRCA2/PALB2-negatively tested breast cancer patients.

PMID 20400964 2010 Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene.

PMID 26824983 2016 Multiple gene sequencing for risk assessment in patients with early-onset or familial breast cancer.

PMID 24800917 2014 Deleterious RAD51C germline mutations rarely predispose to breast and ovarian cancer in Pakistan.

PMID 21990120 2012 Analysis of RAD51C germline mutations in high-risk breast and ovarian cancer families and ovarian cancer patients.

PMID 22725699 2013 Germline RAD51C mutations in ovarian cancer susceptibility.

rs1555605074 in LOC105371843;RAD51C gene and Neoplastic Syndromes, Hereditary PMID 27616075 2017 Gene panel sequencing in familial breast/ovarian cancer patients identifies multiple novel mutations also in genes others than BRCA1/2.

PMID 23500037 2013 Regulation of nonsense-mediated mRNA decay: implications for physiology and disease.

PMID 21447597 2011 UniProt Knowledgebase: a hub of integrated protein data.

PMID 26261251 2015 Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population.

PMID 26720728 2016 Inherited Mutations in Women With Ovarian Carcinoma.

PMID 25452441 2015 Inherited mutations in 17 breast cancer susceptibility genes among a large triple-negative breast cancer cohort unselected for family history of breast cancer.

PMID 22538716 2012 Germline RAD51C mutations confer susceptibility to ovarian cancer.

PMID 27621404 2016 Conflicting Interpretation of Genetic Variants and Cancer Risk by Commercial Laboratories as Assessed by the Prospective Registry of Multiplex Testing.

PMID 28905878 2017 Detecting splicing patterns in genes involved in hereditary breast and ovarian cancer.

PMID 26057125 2015 Mutation Analysis of the RAD51C and RAD51D Genes in High-Risk Ovarian Cancer Patients and Families from the Czech Republic.

PMID 24139550 2013 Germline mutation in the RAD51B gene confers predisposition to breast cancer.

PMID 26822949 2016 Hereditary truncating mutations of DNA repair and other genes in BRCA1/BRCA2/PALB2-negatively tested breast cancer patients.

PMID 29054568 2017 Genetic epidemiology of ovarian cancer and prospects for polygenic risk prediction.

PMID 12442171 2002 Insights into DNA recombination from the structure of a RAD51-BRCA2 complex.