Gene: LOC107984111

Alternate names for this Gene:

Gene Summary:

Gene is located in Chromosome:

Location in Chromosome :

Description of this Gene:

Type of Gene:

Gene: WNT10A

Alternate names for this Gene: OODD|SSPS|STHAG4

Gene Summary: The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is strongly expressed in the cell lines of promyelocytic leukemia and Burkitt's lymphoma. In addition, it and another family member, the WNT6 gene, are strongly coexpressed in colorectal cancer cell lines. The gene overexpression may play key roles in carcinogenesis through activation of the WNT-beta-catenin-TCF signaling pathway. This gene and the WNT6 gene are clustered in the chromosome 2q35 region.

Gene is located in Chromosome: 2

Location in Chromosome : 2q35

Description of this Gene: Wnt family member 10A

Type of Gene: protein-coding

rs146460077 in LOC107984111;WNT10A gene and TOOTH AGENESIS, SELECTIVE, 4 (disorder) PMID 27657131 2016 Eight Mutations of Three Genes (EDA, EDAR, and WNT10A) Identified in Seven Hypohidrotic Ectodermal Dysplasia Patients.

PMID 22581971 2012 Mutations in WNT10A are present in more than half of isolated hypodontia cases.

PMID 29178643 2017 Role of WNT10A in failure of tooth development in humans and zebrafish.

PMID 24311251 2014 WNT10A mutations also associated with agenesis of the maxillary permanent canines, a separate entity.

PMID 23401279 2013 Mutations in WNT10A are frequently involved in oligodontia associated with minor signs of ectodermal dysplasia.

PMID 21484994 2011 WNT10A and isolated hypodontia.

PMID 20979233 2011 Only four genes (EDA1, EDAR, EDARADD, and WNT10A) account for 90% of hypohidrotic/anhidrotic ectodermal dysplasia cases.

PMID 24449199 2014 WNT10A mutations account for ¼ of population-based isolated oligodontia and show phenotypic correlations.