Gene: LOC112268043

Alternate names for this Gene:

Gene Summary:

Gene is located in Chromosome:

Location in Chromosome :

Description of this Gene:

Type of Gene:

Gene: MOB3B

Alternate names for this Gene: C9orf35|MOB1D|MOBKL2B

Gene Summary: The protein encoded by this gene shares similarity with the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. This gene is located on the opposite strand as the interferon kappa precursor (IFNK) gene.

Gene is located in Chromosome: 9

Location in Chromosome : 9p21.2

Description of this Gene: MOB kinase activator 3B

Type of Gene: protein-coding

rs903603 in LOC112268043;MOB3B gene and Amyotrophic Lateral Sclerosis PMID 20801717 2010 Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study.

PMID 23587638 2013 Genome-wide association testing was performed first using all samples, and then restricting the analysis to samples not carrying the mutation. rs3849942 and rs903603 were strongly associated with ALS when all samples were included (rs3849942, p = [3 × 2] × 10(-6), rank 7/442,057; rs903603, p = [7 × 6] × 10(-8), rank 2/442,057).