Gene: MACROD2

Alternate names for this Gene: C20orf133|C2orf133

Gene Summary: The protein encoded by this gene is a deacetylase involved in removing ADP-ribose from mono-ADP-ribosylated proteins. The encoded protein has been shown to translocate from the nucleus to the cytoplasm upon DNA damage.

Gene is located in Chromosome: 20

Location in Chromosome : 20p12.1

Description of this Gene: mono-ADP ribosylhydrolase 2

Type of Gene: protein-coding

rs73898513 in MACROD2 gene and Age at menarche PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs6042935 in MACROD2 gene and Antiphospholipid antibodies measurement PMID 27098658 2016 Antiphospholipid antibodies in a large population-based cohort: genome-wide associations and effects on monocyte gene expression.

rs4141463 in MACROD2 gene and Autistic Disorder PMID 20663923 2010 A genome-wide scan for common alleles affecting risk for autism.

PMID 22843504 2012 Individual common variants exert weak effects on the risk for autism spectrum disorders.

rs6079468 in MACROD2 gene and Bipolar Disorder PMID 22182935 2013 Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder.

rs11908097 in MACROD2 gene and Blood Protein Measurement PMID 29875488 2018 Genomic atlas of the human plasma proteome.

PMID 30072576 2018 Co-regulatory networks of human serum proteins link genetics to disease.

rs16996644 in MACROD2 gene and Body mass index PMID 30239722 2019 Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.

PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

PMID 26426971 2015 The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.

PMID 25673413 2015 Genetic studies of body mass index yield new insights for obesity biology.

rs71190156 in MACROD2 gene and Child Development Disorders, Pervasive PMID 30804558 2019 Identification of common genetic risk variants for autism spectrum disorder.

rs200744 in MACROD2 gene and Corneal Topography PMID 22003120 2011 Association of polymorphisms in the hepatocyte growth factor gene promoter with keratoconus.

rs6079463 in MACROD2 gene and Depressed bipolar I disorder PMID 31043756 2019 Genome-wide association study identifies 30 loci associated with bipolar disorder.

rs6034146 in MACROD2 gene and Duration of sleep PMID 30846698 2019 Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates.

rs6105452 in MACROD2 gene and Epstein-Barr Virus Infections PMID 28654678 2017 Genetic factors affecting EBV copy number in lymphoblastoid cell lines derived from the 1000 Genome Project samples.

rs1041606 in MACROD2 gene and Glomerular Filtration Rate PMID 31152163 2019 A catalog of genetic loci associated with kidney function from analyses of a million individuals.

rs765488291 in MACROD2 gene and Hip circumference PMID 28552196 2017 Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.

rs200752 in MACROD2 gene and Hypertensive disease PMID 21626137 2011 Two-marker association tests yield new disease associations for coronary artery disease and hypertension.

rs6034019 in MACROD2 gene and Intelligence PMID 29326435 2019 A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence.

PMID 29844566 2018 Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.

rs465757 in MACROD2 gene and Interleukin 10 Measurement PMID 27989323 2017 Genome-wide Association Study Identifies 27 Loci Influencing Concentrations of Circulating Cytokines and Growth Factors.

rs10485775 in MACROD2 gene and Leukemia, Myelocytic, Acute PMID 27903959 2017 Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.

rs6110278 in MACROD2 gene and Platelet mean volume determination (procedure) PMID 19820697 2009 A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.

rs6110524 in MACROD2 gene and Secondary malignant neoplasm of colon and/or rectum PMID 30738427 2019 A genome-wide association study identifies single nucleotide polymorphisms associated with time-to-metastasis in colorectal cancer.

rs2423958 in MACROD2 gene and mathematical ability PMID 30038396 2018 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.