Gene: MADD

Alternate names for this Gene: DEEAH|DENN|IG20|NEDDISH|RAB3GEP

Gene Summary: Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene.

Gene is located in Chromosome: 11

Location in Chromosome : 11p11.2

Description of this Gene: MAP kinase activating death domain

Type of Gene: protein-coding

Gene: MADD-AS1

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rs10501320 in MADD;MADD-AS1 gene and Alzheimer's Disease PMID 30805717 2019 Shared genetic architecture between metabolic traits and Alzheimer's disease: a large-scale genome-wide cross-trait analysis.

rs10501320 in MADD;MADD-AS1 gene and Anxiety PMID 29942085 2018 Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.

rs10501320 in MADD;MADD-AS1 gene and Fasting blood glucose measurement PMID 30805717 2019 Shared genetic architecture between metabolic traits and Alzheimer's disease: a large-scale genome-wide cross-trait analysis.

rs10501320 in MADD;MADD-AS1 gene and Insulin measurement PMID 21873549 2011 Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.

rs10501320 in MADD;MADD-AS1 gene and Nervousness PMID 29500382 2018 Item-level analyses reveal genetic heterogeneity in neuroticism.