Gene: MAPK14

Alternate names for this Gene: CSBP|CSBP1|CSBP2|CSPB1|EXIP|Mxi2|PRKM14|PRKM15|RK|SAPK2A|p38|p38ALPHA

Gene Summary: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Gene is located in Chromosome: 6

Location in Chromosome : 6p21.31

Description of this Gene: mitogen-activated protein kinase 14

Type of Gene: protein-coding

rs80028505 in MAPK14 gene and Diabetes Mellitus, Insulin-Dependent PMID 28672053 2017 A genome-wide association study suggests that MAPK14 is associated with diabetic foot ulcers.

rs80028505 in MAPK14 gene and Diabetes Mellitus, Non-Insulin-Dependent PMID 28672053 2017 A genome-wide association study suggests that MAPK14 is associated with diabetic foot ulcers.

rs80028505 in MAPK14 gene and Diabetic Foot PMID 28672053 2017 A genome-wide association study suggests that MAPK14 is associated with diabetic foot ulcers.

rs80028505 in MAPK14 gene and Hereditary and idiopathic neuropathy, unspecified PMID 28672053 2017 A genome-wide association study suggests that MAPK14 is associated with diabetic foot ulcers.

rs80028505 in MAPK14 gene and NEUROPATHY, CONGENITAL HYPOMYELINATING, 2 PMID 28672053 2017 A genome-wide association study suggests that MAPK14 is associated with diabetic foot ulcers.

rs80028505 in MAPK14 gene and NEUROPATHY, CONGENITAL HYPOMYELINATING, 3 PMID 28672053 2017 A genome-wide association study suggests that MAPK14 is associated with diabetic foot ulcers.

rs80028505 in MAPK14 gene and Neuropathy PMID 28672053 2017 A genome-wide association study suggests that MAPK14 is associated with diabetic foot ulcers.