Gene: MARCHF8
Alternate names for this Gene: CMIR|MARCH-VIII|MARCH8|MIR|RNF178|c-MIR
Gene Summary: MARCH8 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH8 induces the internalization of several membrane glycoproteins (Goto et al., 2003 [PubMed 12582153]; Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Apr 2010].
Gene is located in Chromosome: 10
Location in Chromosome : 10q11.21-q11.22
Description of this Gene: membrane associated ring-CH-type finger 8
Type of Gene: protein-coding