Gene: MCM6

Alternate names for this Gene: MCG40308|Mis5|P105MCM

Gene Summary: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, influence lactose intolerance in early adulthood.

Gene is located in Chromosome: 2

Location in Chromosome : 2q21.3

Description of this Gene: minichromosome maintenance complex component 6

Type of Gene: protein-coding

rs4988235 in MCM6 gene and Blood Protein Measurement PMID 29875488 2018 Genomic atlas of the human plasma proteome.

PMID 30072576 2018 Co-regulatory networks of human serum proteins link genetics to disease.

rs4988235 in MCM6 gene and Body mass index PMID 26426971 2015 The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.

PMID 30108127 2018 A Large Multiethnic Genome-Wide Association Study of Adult Body Mass Index Identifies Novel Loci.

rs4988198 in MCM6 gene and Diabetes Mellitus, Non-Insulin-Dependent PMID 28736931 2018 Genetic Variants in HSD17B3, SMAD3, and IPO11 Impact Circulating Lipids in Response to Fenofibrate in Individuals With Type 2 Diabetes.

rs182549 in MCM6 gene and ECOG Performance Status 1 PMID 28588231 2017 Genome-wide association study of 1,5-anhydroglucitol identifies novel genetic loci linked to glucose metabolism.

rs4988235 in MCM6 gene and Hip circumference PMID 25673412 2015 New genetic loci link adipose and insulin biology to body fat distribution.

rs182549 in MCM6 gene and Mild Adverse Event PMID 28588231 2017 Genome-wide association study of 1,5-anhydroglucitol identifies novel genetic loci linked to glucose metabolism.

rs182549 in MCM6 gene and Neck Pain Score 1 PMID 28588231 2017 Genome-wide association study of 1,5-anhydroglucitol identifies novel genetic loci linked to glucose metabolism.

rs4988198 in MCM6 gene and response to simvastatin PMID 28736931 2018 Genetic Variants in HSD17B3, SMAD3, and IPO11 Impact Circulating Lipids in Response to Fenofibrate in Individuals With Type 2 Diabetes.