Gene: MEIS1

Alternate names for this Gene: -

Gene Summary: Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins.

Gene is located in Chromosome: 2

Location in Chromosome : 2p14

Description of this Gene: Meis homeobox 1

Type of Gene: protein-coding

rs113851554 in MEIS1 gene and Circadian Rhythms PMID 27992416 2017 Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits.

PMID 30120083 2018 Genome-Wide Association Study of Circadian Rhythmicity in 71,500 UK Biobank Participants and Polygenic Association with Mood Instability.

rs113851554 in MEIS1 gene and Duration of sleep PMID 30531941 2018 GWAS identifies 14 loci for device-measured physical activity and sleep duration.

PMID 27992416 2017 Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits.

rs10865355 in MEIS1 gene and Electrocardiogram: P-R interval PMID 21347284 2011 Genome-wide association studies of the PR interval in African Americans.

PMID 31217584 2019 Genetic analyses of diverse populations improves discovery for complex traits.

PMID 20062060 2010 Genome-wide association study of PR interval.

PMID 23139255 2012 Novel loci associated with PR interval in a genome-wide association study of 10 African American cohorts.

PMID 30046033 2018 PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity.

PMID 30679814 2019 Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits.

rs11692361 in MEIS1 gene and Endometriosis PMID 27506219 2017 Pooling-Based Genome-Wide Association Study Identifies Risk Loci in the Pathogenesis of Ovarian Endometrioma in Chinese Han Women.

rs2280334 in MEIS1 gene and High density lipoprotein measurement PMID 30275531 2018 Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.

rs11897119 in MEIS1 gene and Physical Activity Measurement PMID 28448500 2017 Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.

rs62144050 in MEIS1 gene and RESTING HEART RATE PMID 27798624 2016 Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality.

rs113851554 in MEIS1 gene and Restless Legs Syndrome PMID 29029846 2017 Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis.

PMID 17637780 2007 Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions.

PMID 21779176 2011 Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1.

rs113851554 in MEIS1 gene and Sleep Initiation and Maintenance Disorders PMID 28604731 2017 Genome-wide association analysis of insomnia complaints identifies risk genes and genetic overlap with psychiatric and metabolic traits.

rs2300481 in MEIS1 gene and Systolic Pressure PMID 30224653 2018 Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.

PMID 30578418 2019 Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.

rs1519104 in MEIS1 gene and Triglycerides measurement PMID 30275531 2018 Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.

PMID 29507422 2018 A large electronic-health-record-based genome-wide study of serum lipids.

rs11897119 in MEIS1 gene and Waist-Hip Ratio PMID 30239722 2019 Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.

PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.