Gene: MICAL2

Alternate names for this Gene: MICAL-2|MICAL2PV1|MICAL2PV2

Gene Summary: The protein encoded by this gene is a monooxygenase that enhances depolymerization of F-actin and is therefore involved in cytoskeletal dynamics. The encoded protein is a regulator of the SRF signaling pathway. Increased expression of this gene has been associated with cancer progression and metastasis.

Gene is located in Chromosome: 11

Location in Chromosome : 11p15.3

Description of this Gene: microtubule associated monooxygenase, calponin and LIM domain containing 2

Type of Gene: protein-coding

rs117250828 in MICAL2 gene and Alzheimer's Disease PMID 26830138 2016 Family-based association analyses of imputed genotypes reveal genome-wide significant association of Alzheimer's disease with OSBPL6, PTPRG, and PDCL3.

rs12291066 in MICAL2 gene and Cerebrovascular accident PMID 26089329 2015 Meta-Analysis of Genome-Wide Association Studies Identifies Genetic Risk Factors for Stroke in African Americans.

rs7105164 in MICAL2 gene and Narcolepsy PMID 19629137 2009 Genome-wide association database developed in the Japanese Integrated Database Project.

rs112421686 in MICAL2 gene and RESTING HEART RATE PMID 27798624 2016 Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality.

rs11022177 in MICAL2 gene and White Blood Cell Count procedure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.