Gene: MIR4773-2

Alternate names for this Gene: -

Gene Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Gene is located in Chromosome: 2

Location in Chromosome : 2q23.3

Description of this Gene: microRNA 4773-2

Type of Gene: ncRNA

Gene: LOC101929319

Alternate names for this Gene:

Gene Summary:

Gene is located in Chromosome:

Location in Chromosome :

Description of this Gene:

Type of Gene:

Gene: TNFAIP6

Alternate names for this Gene: TSG-6|TSG6

Gene Summary: The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. This gene can be induced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis.

Gene is located in Chromosome: 2

Location in Chromosome : 2q23.3

Description of this Gene: TNF alpha induced protein 6

Type of Gene: protein-coding

rs34954281 in MIR4773-2;LOC101929319;TNFAIP6 gene and Diabetes Mellitus, Non-Insulin-Dependent PMID 31264924 2019 A genome-wide association study implicates that the TTC39C gene is associated with diabetic maculopathy with decreased visual acuity.

rs34954281 in MIR4773-2;LOC101929319;TNFAIP6 gene and Maculopathy with diabetes mellitus PMID 31264924 2019 A genome-wide association study implicates that the TTC39C gene is associated with diabetic maculopathy with decreased visual acuity.