Gene: MLLT10

Alternate names for this Gene: AF10

Gene Summary: This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene is located in Chromosome: 10

Location in Chromosome : 10p12.31

Description of this Gene: MLLT10 histone lysine methyltransferase DOT1L cofactor

Type of Gene: protein-coding

rs11012737 in MLLT10 gene and Biliary calculi PMID 30504769 2018 Genome-wide association meta-analysis yields 20 loci associated with gallstone disease.

rs11012732 in MLLT10 gene and Body mass index PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

PMID 30239722 2019 Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.

rs7098100 in MLLT10 gene and Breast Carcinoma PMID 29059683 2017 Association analysis identifies 65 new breast cancer risk loci.

rs12246842 in MLLT10 gene and Duration of sleep PMID 30846698 2019 Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates.

rs1243180 in MLLT10 gene and Epithelial ovarian cancer PMID 25581431 2015 Identification of six new susceptibility loci for invasive epithelial ovarian cancer.

rs1243180 in MLLT10 gene and Malignant neoplasm of ovary PMID 23535730 2013 GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.

rs11012732 in MLLT10 gene and Meningioma PMID 21804547 2011 We identified a new susceptibility locus for meningioma at 10p12.31 (MLLT10, rs11012732, odds ratio = 1.46, P(combined) = 1.88 × 10(-14)).

rs144962376 in MLLT10 gene and Ovarian Serous Adenocarcinoma PMID 28346442 2017 Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer.

rs564819152 in MLLT10 gene and Physical Activity Measurement PMID 30531941 2018 GWAS identifies 14 loci for device-measured physical activity and sleep duration.

rs11012732 in MLLT10 gene and Vital capacity PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs10828247 in MLLT10 gene and Waist-Hip Ratio PMID 30239722 2019 Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.

rs12253527 in MLLT10 gene and body fat percentage (physical finding) PMID 30593698 2019 Genomics of body fat percentage may contribute to sex bias in anorexia nervosa.

rs1243180 in MLLT10 gene and ovarian neoplasm PMID 23535730 2013 GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.

PMID 28346442 2017 Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer.