Gene: MTNR1B

Alternate names for this Gene: FGQTL2|MEL-1B-R|MT2

Gene Summary: This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin.

Gene is located in Chromosome: 11

Location in Chromosome : 11q14.3

Description of this Gene: melatonin receptor 1B

Type of Gene: protein-coding

rs10830963 in MTNR1B gene and Birth Weight PMID 31043758 2019 Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors.

PMID 27680694 2016 Genome-wide associations for birth weight and correlations with adult disease.

PMID 29309628 2018 Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics.

rs10830963 in MTNR1B gene and Body mass index PMID 22581228 2012 A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.

rs10830963 in MTNR1B gene and Diabetes Mellitus, Non-Insulin-Dependent PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

PMID 22885922 2012 Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.

PMID 28869590 2017 Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.

PMID 30054458 2018 Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes.

PMID 24509480 2014 Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.

PMID 28254843 2017 Genetics of Type 2 Diabetes in U.S. Hispanic/Latino Individuals: Results From the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).

rs10830963 in MTNR1B gene and Fasting blood glucose measurement PMID 22581228 2012 A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.

PMID 31021400 2019 Pleiotropy informed adaptive association test of multiple traits using genome-wide association study summary data.

PMID 25631608 2015 Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility.

PMID 22885924 2012 Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.

PMID 22508271 2012 Fasting glucose GWAS candidate region analysis across ethnic groups in the Multiethnic Study of Atherosclerosis (MESA).

PMID 29844224 2018 Genome-Wide Association Study of Serum Fructosamine and Glycated Albumin in Adults Without Diagnosed Diabetes: Results From the Atherosclerosis Risk in Communities Study.

PMID 29743933 2018 Fast and Accurate Genome-Wide Association Test of Multiple Quantitative Traits.

PMID 19060907 2009 Variants in MTNR1B influence fasting glucose levels.

PMID 31217584 2019 Genetic analyses of diverse populations improves discovery for complex traits.

PMID 23251661 2012 Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.

PMID 20081858 2010 New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.

rs10830963 in MTNR1B gene and Fasting blood sugar result PMID 22885924 2012 Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.

rs10830963 in MTNR1B gene and Glucose tolerance test PMID 29743933 2018 Fast and Accurate Genome-Wide Association Test of Multiple Quantitative Traits.

rs10830963 in MTNR1B gene and Insulin Sensitivity Measurement PMID 24699409 2014 A central role for GRB10 in regulation of islet function in man.

rs10830963 in MTNR1B gene and Insulin measurement PMID 24699409 2014 A central role for GRB10 in regulation of islet function in man.

rs10830963 in MTNR1B gene and Polysomnography PMID 23251661 2012 Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.

rs10830963 in MTNR1B gene and Serum albumin measurement PMID 22286219 2012 Genome-wide association study identifies multiple loci influencing human serum metabolite levels.