Gene: MYO1E

Alternate names for this Gene: FSGS6|HuncM-IC|MYO1C

Gene Summary: This gene encodes a member of the nonmuscle class I myosins which are a subgroup of the unconventional myosin protein family. The unconventional myosin proteins function as actin-based molecular motors. Class I myosins are characterized by a head (motor) domain, a regulatory domain and a either a short or long tail domain. Among the class I myosins, this protein is distinguished by a long tail domain that is involved in crosslinking actin filaments. This protein localizes to the cytoplasm and may be involved in intracellular movement and membrane trafficking. Mutations in this gene are the cause of focal segmental glomerulosclerosis-6. This gene has been referred to as myosin IC in the literature but is distinct from the myosin IC gene located on chromosome 17.

Gene is located in Chromosome: 15

Location in Chromosome : 15q22.2

Description of this Gene: myosin IE

Type of Gene: protein-coding

rs7175642 in MYO1E gene and Body mass index PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs2306786 in MYO1E gene and Calcification of coronary artery PMID 22916037 2012 Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.

rs387906807 in MYO1E gene and FOCAL SEGMENTAL GLOMERULOSCLEROSIS 6 PMID 21756023 2011 MYO1E mutations and childhood familial focal segmental glomerulosclerosis.

PMID 21697813 2011 Exome sequencing identified MYO1E and NEIL1 as candidate genes for human autosomal recessive steroid-resistant nephrotic syndrome.

rs11632157 in MYO1E gene and Serum albumin measurement PMID 22286219 2012 Genome-wide association study identifies multiple loci influencing human serum metabolite levels.