Gene: NCALD

Alternate names for this Gene: -

Gene Summary: This gene encodes a member of the neuronal calcium sensor (NCS) family of calcium-binding proteins. The protein contains an N-terminal myristoylation signal and four EF-hand calcium binding loops. The protein is cytosolic at resting calcium levels; however, elevated intracellular calcium levels induce a conformational change that exposes the myristoyl group, resulting in protein association with membranes and partial co-localization with the perinuclear trans-golgi network. The protein is thought to be a regulator of G protein-coupled receptor signal transduction. Several alternatively spliced variants of this gene have been determined, all of which encode the same protein; additional variants may exist but their biological validity has not been determined.

Gene is located in Chromosome: 8

Location in Chromosome : 8q22.3

Description of this Gene: neurocalcin delta

Type of Gene: protein-coding

rs12544026 in NCALD gene and Alcohol-Induced Disorders PMID 29071344 2017 Genetic Risk Variants Associated With Comorbid Alcohol Dependence and Major Depression.

rs12544026 in NCALD gene and Alcohol-Related Disorders PMID 29071344 2017 Genetic Risk Variants Associated With Comorbid Alcohol Dependence and Major Depression.

rs12544026 in NCALD gene and Alcoholic Intoxication, Chronic PMID 29071344 2017 Genetic Risk Variants Associated With Comorbid Alcohol Dependence and Major Depression.

rs1074703 in NCALD gene and Cardiovascular Diseases PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs12544026 in NCALD gene and Major Depressive Disorder PMID 29071344 2017 Genetic Risk Variants Associated With Comorbid Alcohol Dependence and Major Depression.

rs636089 in NCALD gene and RDW - Red blood cell distribution width result PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs636089 in NCALD gene and Red cell distribution width determination PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs142449193 in NCALD gene and Systolic Pressure PMID 30224653 2018 Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.