Gene: NCAM1
Alternate names for this Gene: CD56|MSK39|NCAM
Gene Summary: This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein has been shown to be involved in development of the nervous system, and for cells involved in the expansion of T cells and dendritic cells which play an important role in immune surveillance. Alternative splicing results in multiple transcript variants.
Gene is located in Chromosome: 11
Location in Chromosome : 11q23.2
Description of this Gene: neural cell adhesion molecule 1
Type of Gene: protein-coding
rs11214489 in
NCAM1 gene and
Blood Protein Measurement
PMID 30111768 2018 Genome-wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease.
PMID 29875488 2018 Genomic atlas of the human plasma proteome.
PMID 30072576 2018 Co-regulatory networks of human serum proteins link genetics to disease.
rs1816537 in
NCAM1 gene and
Body mass index
PMID 30108127 2018 A Large Multiethnic Genome-Wide Association Study of Adult Body Mass Index Identifies Novel Loci.
PMID 25673413 2015 Genetic studies of body mass index yield new insights for obesity biology.
PMID 26426971 2015 The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.
PMID 30239722 2019 Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.
rs4471463 in
NCAM1 gene and
Cannabis use
PMID 27023175 2016 Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium.
PMID 30150663 2018 GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia.
rs1436109 in
NCAM1 gene and
Diagnostic Techniques, Cardiovascular
PMID 21212386 2011 Genetic variation in NCAM1 contributes to left ventricular wall thickness in hypertensive families.
rs1940700 in
NCAM1 gene and
High density lipoprotein measurement
PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
rs11214475 in
NCAM1 gene and
Intelligence
PMID 29844566 2018 Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.
PMID 31374203 2019 Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways.
PMID 29942086 2018 Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence.
rs1436109 in
NCAM1 gene and
Left Ventricular Hypertrophy
PMID 21212386 2011 Genetic variation in NCAM1 contributes to left ventricular wall thickness in hypertensive families.
rs1436109 in
NCAM1 gene and
Left ventricular mass
PMID 21212386 2011 Genetic variation in NCAM1 contributes to left ventricular wall thickness in hypertensive families.
rs668204 in
NCAM1 gene and
Leukemia, Myelocytic, Acute
PMID 27903959 2017 Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.
rs1940709 in
NCAM1 gene and
Major Depressive Disorder
PMID 29942085 2018 Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.
rs1940709 in
NCAM1 gene and
Mood Disorders
PMID 29942085 2018 Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.
rs12574893 in
NCAM1 gene and
Schizophrenia
PMID 31374203 2019 Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways.
rs1940700 in
NCAM1 gene and
Serum HDL cholesterol measurement
PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
rs2155287 in
NCAM1 gene and
Serum albumin measurement
PMID 22286219 2012 Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
rs61902492 in
NCAM1 gene and
Smoking
PMID 30643258 2019 Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences.
rs10891499 in
NCAM1 gene and
Systolic Pressure
PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
PMID 27841878 2017 Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation.
rs10891483 in
NCAM1 gene and
Waist-Hip Ratio
PMID 30575882 2018 Association of Genetic Variants Related to Gluteofemoral vs Abdominal Fat Distribution With Type 2 Diabetes, Coronary Disease, and Cardiovascular Risk Factors.
rs2155292 in
NCAM1 gene and
mathematical ability
PMID 30038396 2018 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.