Gene: NCK2

Alternate names for this Gene: GRB4|NCKbeta

Gene Summary: This gene encodes a member of the NCK family of adaptor proteins. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene is located in Chromosome: 2

Location in Chromosome : 2q12.2

Description of this Gene: NCK adaptor protein 2

Type of Gene: protein-coding

rs2377339 in NCK2 gene and Addictive Behavior PMID 23533358 2013 NCK2 is significantly associated with opiates addiction in African-origin men.

rs7589790 in NCK2 gene and Eosinophil count procedure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs11124063 in NCK2 gene and Platelet Component Distribution Width Measurement PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

rs12995333 in NCK2 gene and Substance-Related Disorders PMID 23533358 2013 NCK2 is significantly associated with opiates addiction in African-origin men.