Gene: NCOA6

Alternate names for this Gene: AIB3|ASC2|NRC|PRIP|RAP250|TRBP

Gene Summary: The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. This protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene is located in Chromosome: 20

Location in Chromosome : 20q11.22

Description of this Gene: nuclear receptor coactivator 6

Type of Gene: protein-coding

Gene: PIGU

Alternate names for this Gene: CDC91L1|GAB1|GPIBD21|NEDBSS

Gene Summary: The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Cdc91, a predicted integral membrane protein that may function in cell division control. The protein encoded by this gene is the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins.

Gene is located in Chromosome: 20

Location in Chromosome : 20q11.22

Description of this Gene: phosphatidylinositol glycan anchor biosynthesis class U

Type of Gene: protein-coding

rs6088580 in NCOA6;PIGU gene and Creatinine measurement, serum (procedure) PMID 26831199 2016 Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function.

rs6088580 in NCOA6;PIGU gene and Glomerular Filtration Rate PMID 26831199 2016 Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function.

rs6059988 in NCOA6;PIGU gene and High density lipoprotein measurement PMID 29507422 2018 A large electronic-health-record-based genome-wide study of serum lipids.