Gene: NCOR1
Alternate names for this Gene: N-CoR|N-CoR1|PPP1R109|TRAC1|hN-CoR
Gene Summary: This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.
Gene is located in Chromosome: 17
Location in Chromosome : 17p12-p11.2
Description of this Gene: nuclear receptor corepressor 1
Type of Gene: protein-coding