Gene: NEK4

Alternate names for this Gene: NRK2|STK2|pp12301

Gene Summary: The protein encoded by this gene is a serine/threonine protein kinase required for normal entry into replicative senescence. The encoded protein also is involved in cell cycle arrest in response to double-stranded DNA damage. Finally, this protein plays a role in maintaining cilium integrity, and defects in this gene have been associated with ciliopathies.

Gene is located in Chromosome: 3

Location in Chromosome : 3p21.1

Description of this Gene: NIMA related kinase 4

Type of Gene: protein-coding

rs12497998 in NEK4 gene and Bipolar Disorder PMID 22182935 2013 Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder.

rs530829730 in NEK4 gene and Blood Protein Measurement PMID 29875488 2018 Genomic atlas of the human plasma proteome.

rs11130319 in NEK4 gene and Body mass index PMID 28892062 2017 Genome-wide association study identifies 112 new loci for body mass index in the Japanese population.

rs80176849 in NEK4 gene and Finding of Mean Corpuscular Hemoglobin PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs10780035 in NEK4 gene and Major Depressive Disorder PMID 22472876 2013 A mega-analysis of genome-wide association studies for major depressive disorder.

rs7620039 in NEK4 gene and Reticulocyte count (procedure) PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.