Gene: NFYC

Alternate names for this Gene: CBF-C|CBFC|H1TF2A|HAP5|HSM|NF-YC

Gene Summary: This gene encodes one subunit of a trimeric complex forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoters of a variety of genes. The encoded protein, subunit C, forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene is located in Chromosome: 1

Location in Chromosome : 1p34.2

Description of this Gene: nuclear transcription factor Y subunit gamma

Type of Gene: protein-coding

rs10489167 in NFYC gene and Bipolar Disorder PMID 26297903 2016 Genetics of long-term treatment outcome in bipolar disorder.

rs7519348 in NFYC gene and Respiratory Function Tests PMID 30845926 2019 Limited overlap in significant hits between genome-wide association studies on two airflow obstruction definitions in the same population.