Gene: OAS3

Alternate names for this Gene: p100|p100OAS

Gene Summary: This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of adenosine in order to bind and activate RNase L. This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance.

Gene is located in Chromosome: 12

Location in Chromosome : 12q24.13

Description of this Gene: 2'-5'-oligoadenylate synthetase 3

Type of Gene: protein-coding

rs2072134 in OAS3 gene and Alcohol consumption PMID 21270382 2011 Genome-wide association studies identify genetic loci related to alcohol consumption in Korean men.

PMID 28485404 2017 Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study.

rs6489882 in OAS3 gene and Chronic Lymphocytic Leukemia PMID 28165464 2017 Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia.

rs2072134 in OAS3 gene and High density lipoprotein measurement PMID 31006500 2020 Protein and fat intake interacts with the haplotype of PTPN11_rs11066325, RPH3A_rs886477, and OAS3_rs2072134 to modulate serum HDL concentrations in middle-aged people.

PMID 30718733 2019 The Korea Biobank Array: Design and Identification of Coding Variants Associated with Blood Biochemical Traits.

rs2010549 in OAS3 gene and Leukemia, Myelocytic, Acute PMID 27903959 2017 Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.

rs6489882 in OAS3 gene and Small Lymphocytic Lymphoma PMID 28165464 2017 Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia.